Internal KCN: Alireza Ghadimi

For next week lab meeting presentation Alireza is going to talk about the following paper and also some of his simulations around it:

"Estimating short-term synaptic plasticity from pre- and postsynaptic spiking"

link: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005738

Abstract: Short Term Plasticity (STP) is one of the phenomena happening on brain cells that have some effect on information processing in the brain; this phenomenon especially has been seen in the basal ganglia network which its dysfunction leads to neurological disorders such as Parkinson's Disease. One of the most common models for STP is called Tsodyks-Markram Model which describes STP from a phenomenological view. In spite of the accurate results of this model on post-synaptic current data which needs in vitro patch clamping, there is no reliable approach for inferring Tsodyks-Markram model's parameters from in vivo experiments. This paper is one of the first efforts that I have found about inferring STP parameter from  in vivo data. I am going to talk about other methods of this problem and also present the proof of concept of some of my works.